@article {633, title = {Anti-arthritic Activity of Ethanolic Extract of Tridax Procumbens (Linn.) in Sprague Dawley Rats}, journal = {Pharmacognosy Research}, volume = {5}, year = {2013}, month = {April 2013}, pages = { 113-117}, type = {Original Article }, chapter = {113}, abstract = {

Objective:\ To determine the anti-arthritic effect of whole plant ethanolic extract of\ Tridax procumbens\ (Asteraceae) in female Sprague Dawley (SD) rats using the Freund{\textquoteright}s Complete Adjuvant (FCA) model.\ Materials and Methods:\ The plant was collected from different regions of Madurai District, Tamil Nadu, and the phytoconstituents were identified through chemical tests. Ethanol (95\%) was used to obtain the whole plant extraction through Soxhlet extractor. Female SD rats were used for anti-arthritic screening. Arthritis was induced using FCA, and the anti-arthritic effect of the ethanolic extract of\ T. procumbens\ was studied at doses of 250 and 500 mg/kg. The effects were compared with those of indomethacin (10 mg/kg). At the end of the study, the liver enzyme levels were determined and a radiological examination was carried out.\ Result:\ The preliminary phytochemical analysis of the ethanolic extract of\ T. procumbens\ indicated the presence of alkaloids, tannins, flavonoids and saponins.\ T. procumbens\ at 250 and 500 mg/kg significantly inhibited the FCA-induced arthritis in the rats. This was manifested by as a decrease in the paw volume. The arthritic control animals exhibited a significant decrease in body weight compared with control animals without arthritis.\ T. procumbens\ animals showed dose dependent reduction in decrees in body weight and arthritis. At the same time,\ T. procumbens\ significantly altered the biochemical and haematological changes induced by FCA (\ P\ \< 0.05). The anti-arthritic effect of\ T. procumbens\ was comparable with that of indomethacin.\ Conclusion:\ The whole plant extract of\ T. procumbens\ showed significant anti-arthritic activity against FCA-induced arthritis in female SD rats.

}, keywords = {Arthritis, Freund's Complete Adjuvant, T. Procumbens}, doi = { 10.4103/0974-8490.110541}, author = {R Ramesh Petchi and C Vijaya and S Parasuraman} }