@article {1471, title = {GC-MS Analysis of an Ayurveda Formulation Erandamula Niruha Basti (Medicated Therapeutic Enema)}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {1071-1076}, type = {Original Article}, chapter = {1071}, abstract = {

Background: The scientific credibility of modern and Indian System of Medicine, such as Ayurveda and Siddha, is highly relevant in the current era. The gas chromatography-mass spectrometry (GC-MS) instrument separates chemical mixtures (the GC component) and identifies the components at a molecular level. Since Basti is the most effective remedy for Vata Dosha, it occupies a prominent position among the five Therapeutic measures of Panchakarma. Aim and Objectives: This study uses Gas Chromatography-Mass Spectrometry (GC-MS) analysis to examine the Erandamula Niruha Basti, with the goal of identifying links between its medicinal properties and the biomolecules it comprises. Materials and Methods: GCMS analysis was conducted using 7890 A GC with 5975C with a triple-axis detector. The compounds were identified after comparing the spectral configurations obtained with those of the available mass spectral database (NIST-08 SPECTRAL DATA). Results: Important compounds were found in the profile that resulted, showing the presence of some important molecules like 5-Acetoxymethyl- 2-furaldehyde,2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one,3-Furanmethanol, and furfural, which exhibit pharmacological actions like anti-inflammatory and antioxidant, which is in keeping with the therapeutic qualities that Eranndamoola Niruha Basti is said to possess. Conclusion: The current study uses GC-MS analysis to demonstrate the scientific validity of conventional formulations such as Erandamoola Niruha Basti. This Ayurvedic remedy{\textquoteright}s pharmacological claims are supported by the finding of important phytochemicals. Certain molecules, like furfural and 5-acetoxymethyl-2-furaldehyde, have antioxidant and anti-inflammatory qualities. These results are consistent with Basti{\textquoteright}s traditional therapeutic benefits in treating Vata disorders. The discovery of these biomolecules validates Erandamula Niruha Basti{\textquoteright}s function as a potent treatment for Vata vyadhi (musculoskeletal disorders) in Ayurveda.

}, keywords = {Anti-inflammatory, Basti, Erandamula niruha Basti, GCMS}, doi = {10.5530/pres.20252174}, author = {Anil Koralli and Pradeep L Gramapurohit and Sunil Jalalpure and Kshama Mutalik and Rashmi R} }