@article {1465, title = {Antioxidant, Stimulating Telomerase and Anxiolytic Activities of Polysaccharide Isolated from Sargentodoxa cuneata}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {1020-1028}, type = {Original Article}, chapter = {1020}, abstract = {

Background: The classic anxiolytics have adverse effects in the treating anxiety disorders. Aim: To identify the anxiolytic polysaccharide from Sargentodoxa cuneata. Materials and Methods: The water-soluble Polysaccharide Fraction (PSC) was purified from S. cuneata, as well as its subfractions PSCA-1 and PSCB-1. The antioxidant effect of PSC against rotenone induced PC12 cell excitotoxicity, stimulating telomerase effect in HEK293T cell and anxiolytic effect on zebrafish were evaluated. Results: The pretreatment of PC12 with PSC obviously increased cell survival and SOD level. PSC also down-regulated the LDH release, ROS level and cell apoptosis rate. PSC promoted the 293T cell proliferation, associated with the mechanism of stimulating telomerase. Additionally, PSC alleviated the anxiety level in zebrafish induced by mCPP. Conclusion: These findings suggested that the PSC could possess the anxiolytic potential via antioxidant and telomerase activation.

}, keywords = {Antioxidant, Anxiety, Polysaccharide, Sargentodoxa cuneata, Telomerase}, doi = {10.5530/pres.20252269}, author = {Jian Tang and Ping Zhou and Huifang Sun and Xiuquan Xu and Chongwei Wen and Haiping Xia} }