@article {1456, title = {GC-MS Analysis of Dhanwanthari Taila: Identification of Bioactive Compounds Supporting its Analgesic and Anti-Inflammatory Potential in Chronic Low Back Pain}, journal = {Pharmacognosy Research}, volume = {17}, year = {2025}, month = {June 2025}, pages = {955-960}, type = {Original Article}, chapter = {955}, abstract = {

Background: The scientific validation of traditional Ayurvedic formulations is crucial for integrating them into modern therapeutic practices. Dhanwanthari Taila, a widely used Ayurvedic medicated oil, is traditionally used for pain management, particularly in musculoskeletal disorders like Chronic Low Back Pain (CLBP). Aim and Objectives: This study utilizes Gas Chromatography-Mass Spectrometry (GC-MS) to analyze the chemical composition of Dhanwanthari Taila, aiming to establish correlations between its bioactive compounds and its therapeutic effects in pain relief. Materials and Methods: A sample (100 mL) of Dhanwanthari Taila was procured from KLE GMP certified Ayurveda Pharmacy and subjected to GC-MS analysis using standard analytical protocols to identify its bioactive components. Results and Discussion: The analysis identified key bioactive compounds, including Glycidyl palmitoleate, Oleic acid, 1-Decyne, 3-Tridecene, and Hexadecanoic acid derivatives, which are known for their anti-inflammatory and analgesic properties. The high concentration of Glycidyl palmitoleate suggests its potential contribution to the oil{\textquoteright}s therapeutic efficacy. These findings align with the traditional use of Dhanwanthari Taila in alleviating pain, inflammation, and stiffness, supporting its role in managing CLBP and related conditions. Conclusion: The presence of these bioactive molecules validates the therapeutic application of Dhanwanthari Taila as an effective pain-relieving formulation. Further research is essential to explore its clinical efficacy and potential integration into conventional pain management strategies.

}, keywords = {Analgesic, Anti-inflammatory, Chronic Low Back Pain, Dhanwanthari Taila, GC-MS}, doi = {10.5530/pres.20252192}, author = {Ramesh Shivappa Killedar and Pradeep Shahjirao Shindhe and Vijay Kage and Raj Joshi} }