@article {1156, title = {Subacute Oral Toxicity Evaluation of Freeze-Dried Fruits of Lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) in ICR Mice}, journal = {Pharmacognosy Research}, volume = {15}, year = {2023}, month = {June 2023}, pages = {504-513}, type = {Original Article }, chapter = {504}, abstract = {

Background: Lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) is an indigenous fruit in the Philippines with potential functions against obesity and non-communicable diseases, but limited literature was available on its safety. Objectives: This study investigated the subacute toxicity effects of freeze-dried fruits of lipote (Syzygium polycephaloides (C.B. Rob.) Merr.) on ICR mice. Materials and Methods: Ten male and ten female 6-week-old ICR mice were divided into two groups: (1) control (vehicle), and (2) lipote group, given with 2000 mg/kg body weight (BW) dose of freeze-dried lipote fruit powder reconstituted in distilled water. Results: After 28 days of oral gavage, the lipote group showed no significant changes on feed and water intake, and hematology and blood chemistry parameters were comparable with those of control group and published normal values. Body weights of all experimental animals also increased significantly (p\<0.05), and no mortality, morbidity, or gross and microscopic morphological abnormalities of internal organs were noted. Conclusion: These results showed that 28-day oral consumption of freeze-dried lipote fruits is safe and has LD50 \>2000 mg/kg.

}, keywords = {Indigenous berries, Lipote, Subacute, Syzygium.}, doi = {10.5530/pres.15.3.053}, author = {Ann C. Cayetano and Liezl M. Atienza and Maria Amelita C. Estacio and Katherine Ann T. Castillo-Israel and Mark Joseph Desamero and Roxanne P. Gapasin and Jonna C. Maniwang and Rohani C. Navarro and Dianne Jane A. Sunico and James Ryan D. Aranzado and Loraine C. Bainto-Ancheta and Joan I. Delomen and Jonina Marie J. Tengco} }