@article {1067, title = {Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats}, journal = {Pharmacognosy Research}, volume = {14}, year = {2022}, month = {July 2022}, pages = {304-309}, type = {Original Article}, chapter = {304}, abstract = {

Background: Euphorbia helioscopia is of the family Euphorbiaceae, owning various pharmacological properties like anti-inflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic disease that can be characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage. Objectives: To assess the anti-arthritic activity of aqueous and ethanolic extracts of Euphorbia helioscopia. Materials and Methods: Adjuvant-induced arthritis (AIA) method was followed for the evaluation. Complete Freund{\textquoteright}s adjuvant (CFA) was used to induce arthritis in female Wistar rats. Aqueous and ethanolic extracts (300, 150, and 75 mg/kg/day) of aerial parts of Euphorbia helioscopia were given orally to Wistar rats. Results: Both the extracts showed significant anti-arthritic activity in a dose-dependent manner. However, ethanolic extract (300mg/kg) of Euphorbia helioscopia showed potential anti-arthritic activity among the tested extracts. Conclusion: From the study, it can be concluded that Euphorbia helioscopia possesses marked anti-arthritic activity.

}, keywords = {Adjuvant induced arthritis, Antiinflammatory, Aqueous and ethanolic plant extracts, Euphorbia helioscopia, Rheumatoid Arthritis}, doi = {10.5530/pres.14.3.44}, author = {Iram Jan and Ashish Dogra and Syed Assim Haq and Sumit Dhiman and Gurdarshan Singh and Mithilesh Kumar} }