Pharmacological Investigation of Actinidia deliciosa Extract in NSAIDs Induced Gastric Ulcer in Rodent Model

Arijit Chaudhuri; Arushi A; Manisha Dhiman; Anshul Thakur; Risha Kumari; Seema Devi; Shilpa Thakur; Ayusha A; Prince P; Nidhika N

Pharmacological Investigation of Actinidia deliciosa Extract in NSAIDs Induced Gastric Ulcer in Rodent Model

Articles

Abstract

Pharmacognosy Research,2025,17,3,801-815.

DOI:10.5530/pres.20252087

Published:June 2025

Type:Review Article

Authors:

Author(s) affiliations:

Arijit Chaudhuri^1,*, Arushi², Manisha Dhiman³, Anshul Thakur¹, Risha Kumari¹, Seema Devi², Shilpa Thakur¹, Ayusha², Prince⁴, Nidhika^{4 ,}

¹Department of Pharmacology, Shiva Institute of Pharmacy Vill-Luhnoo Kanatain, Chandpur, Bilaspur, Himachal Pradesh, INDIA.

²Department of Pharmaceutics, Shiva Institute of Pharmacy Vill-Luhnoo Kanatain, Chandpur, Bilaspur, Himachal Pradesh, INDIA.

³Department of Pharmacognosy, Shiva Institute of Pharmacy Vill-Luhnoo Kanatain, Chandpur, Bilaspur, Himachal Pradesh, INDIA.

⁴Department of Pharmacy, Shiva Institute of Pharmacy Vill-Luhnoo Kanatain, Chandpur, Bilaspur, Himachal Pradesh, INDIA.

Abstract:

NSAIDs or non opoidal agents are commonly employed to treat rubor, dolor, relieve pain, but they often cause Gastrointestinal (GI) side effects, including gastritis, ulceration and bleeding. Natural products have emerged as potential alternatives or adjuncts to conventional treatments. The purpose of this study is to look at how Actinidia deliciosa (kiwi) extract protects against gastric ulcer brought on by NSAIDs. Background: NSAIDs are a group of pharmaceutical medications that are usually employed to treat rubor and dolor along with pyrexia as well as give a certain analgesic action at a certain therapeutic dose. At certain doses it is also used treat some sort of discomfort. While effective for these purposes, NSAIDs can also cause significant Gastrointestinal (GI) side effects, leading to conditions like gastritis, ulcers and even bleeding. This condition is known as NSAIDs-induced gastric ulcer. Materials and Methods: Rats will be divided into control, NSAIDs-induced gastric ulcer and NSAIDs-induced gastric ulcer treated with Actinidia deliciosa extract groups. The NSAIDs-induced gastric ulcer model will be established using indomethacin. The extract will be administered orally at various doses for a specified duration. GI damage will be assessed by measuring ulcer index, histological examination and biochemical markers (e.g., myeloperoxidase, malondialdehyde). The antioxidant activity of the extract will also be evaluated. Results: Preliminary findings suggest that Actinidia deliciosa extract significantly reduces NSAIDs-induced GI damage. It may exert its protective effects through antioxidant properties, inhibition of inflammatory mediators and mucosal barrier enhancement. Conclusion: Actinidia deliciosa extract shows promise as a potential natural agent for preventing NSAIDs-induced gastric ulcer. Further studies are warranted to elucidate the underlying mechanisms, determine the optimal dosage and administration route.