Formulation and Evaluation of Jatropha curcas Latex Based Gel for the Treatment of Canker Sores

Background: The recent food habits of the people causing severe health issues. One of the most relevant oral problems that disturb the daily life of the people is canker sores. The latex of Jatropha curcas can be used as a promising agent to treat canker sore. Objectives: The latex of Jatropha curcas was found to hold the capability to boost the speedy curing of the canker sores in the mouth. Materials and Methods: The activity of Jatropha curcas was compared with Solanum nigrum, which was already proven to be used as an ingredient in the formulation of various oral related drugs products. The activity of latex of Jatropha curcas in terms of anti-bacterial, antioxidant and anti-inflammatory assays have been analyzed and compared with leaves of Solanum nigrum. Results: Six different formulations of Jatropha curcas latex based gel was prepared and subjected to evaluation of physicochemical properties. Conclusion: The cytotoxicity studies of the formulations were performed to assess the cellular growth in the presence and absence of active ingredients in the formulations. The IC₅₀ values were also determined to find the minimal concentration to inhibit 50% of cell population.