Natural Gastroprotective Remedy from the Branches of Spondias tuberosa Arruda

Amanda Dias de Araujo; George Souza Feitoza; Fernanda Granja da Silva Oliveira; Bruno Oliveira de Veras; Francinete Francis Lacerda; Nicácio Henrique da Silva; Wolfgang Harand; Silvania T Paz; Mário Ribeiro de Melo-Júnior; Jackson Roberto Guedes

Natural Gastroprotective Remedy from the Branches of Spondias tuberosa Arruda

Articles

Abstract

Pharmacognosy Research,2020,12,4,455-459.

DOI:10.4103/pr.pr_43_20

Published:January 2021

Type:Original Article

Authors:

Author(s) affiliations:

Amanda Dias de Araujo¹, George Souza Feitoza², Fernanda Granja da Silva Oliveira³, Bruno Oliveira de Veras⁴, Francinete Francis Lacerda⁵, Nicácio Henrique da Silva², Wolfgang Harand¹, Silvania T Paz⁶, Mário Ribeiro de Melo-Júnior⁶, Jackson Roberto Guedes da Silva Almeida³, Marcia Vanusa da Silva¹, Maria Tereza dos Santos Correia²

¹Departments of Biochemistry, Federal University of Pernambuco; National Institute of Semiarid/Ministry of Science, Technology and Innovation (INSA/MCTI), Paraiba, BRAZIL.

²Departments of Biochemistry, Federal University of Pernambuco, Paraiba, BRAZIL.

³Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Pernambuco, Brazil

⁴Department of Biochemistry, Federal University of Pernambuco, Paraiba; Post-Graduation in Tropical Medicine, Federal University of Pernambuco, BRAZIL.

⁵Agronomic Institute of Pernambuco – IPA, BRAZIL.

⁶Department of Pathology, Federal University of Pernambuco, BRAZIL.

Abstract:

Background: Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. Several species of Spondias are used in traditional medicine for the treatment of gastrointestinal diseases, infections, and inflammation, among other conditions. Objectives: The aim of this study was to investigate the antioxidant properties in vitro and gastroprotective effect in mice of the methanolic extract of branches of Spondias tuberosa (MEB). MEB was screened for antioxidant activities using different methods. Materials and Methods: Measurements of total phenolic compounds, flavonoids, and tannins were also evaluated. The profile of phenolic compounds of extract was performed by high-performance liquid chromatography (HPLC). MEB was investigated for acute and chronic toxicity and gastroprotective effects against ethanol-induced lesions in Swiss mice. Results: The extract showed antioxidant activity in vitro and high content of phenolic compounds, flavonoids, and tannins. The HPLC results identified the presence of gallic acid, chlorogenic acid, caffeic acid, and t-ferulic acid. The MEB showed no acute and chronic toxicity and in doses of 50, 100 and 200 mg/kg, v. o., reduced the area of ulcerative lesions induced by ethanol in 73.74, 72.02, and 72.40', respectively. Conclusion: The oral treatment with the extract of S. tuberosa branches (MEB) showed gastroprotective and antioxidant activities.