ArticlesAbstractPharmacognosy Research,2019,11,4,406-409.DOI:10.4103/pr.pr_17_17Published:November,2019Type:Original ArticleAuthors:Thonangi Chandi Vishala, Gummalla Pitchaiah, D. Pravadha, and Akula Annapurna Author(s) affiliations:Thonangi Chandi Vishala1, Gummalla Pitchaiah2, D Pravadha1, Akula Annapurna1 1 Division of Pharmacology, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India. 2 Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. Abstract:Objectives: The present study was designed to evaluate the antioxidant and Nootropic activities of Emblica officinalis against aluminum‑induced Alzheimer’s disease (AD) in Wistar rats. Materials and Methods: Alzheimer’s was induced using aluminum chloride at a dose of 4.2 mg/kg by intraperitoneal route for 28 days. In prophylactic studies, the plain amla powder (500 mg/kg) and fortified amla powder (300 mg/kg) were administered along with the aluminum chloride. In the curative study, the fortified amla powder (500 mg/kg) was administered to Alzheimer’s‑induced rats. Memory impairment was confirmed by measuring the nootropic activity using Morris water maize. At the end of the treatment, the oxidative stress parameters such as malondialdehyde (MDA), superoxide dismutase (SOD), and catalase were evaluated. Results: The present study showed statistically significant increase in nootropic activity in terms of decrease in latency period in treatment groups when compared with the controlled Alzheimer’s‑induced group. The administration of amla fruit powder (plain and fortified) decreased the MDA levels and increased the SOD and catalase levels. Conclusion: The present study proved that E. officinalis is a promising tool in antioxidant and neuroprotective activity against aluminum chloride‑induced AD. Keywords:Aluminum chloride, Alzheimer’s, Amla fruit powder, Antioxidant, Fortification, Nootropic.View:PDF (695.23 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Effect of Plain and Fortified Amla Fruit Powder on Aluminum‑induced Alzheimer’s Disease in Wistar Rats KeywordsAluminum chlorideAlzheimer’sAmla fruit powderAntioxidantFortificationNootropic. ‹ Antioxidant Potential of Ethanolic Extract of Canavalia Species in High‑fat Diet and Streptozotocin‑induced Diabetic Rats up Carqueja (Baccharis trimera) Essential Oil Chronic Treatment Induces Ventricular Repolarization Disorder in Healthy Rats but Not in Type 2 Diabetic Rats ›