ArticlesAbstractPharmacognosy Research,2013,5,2,129-133.DOI:10.4103/0974-8490.110544 Published:April 2013Type:Original Article Authors:Roslida Abdul Hamid, Teoh Hui Kee, and Fezah Othman Author(s) affiliations:Roslida Abdul Hamid, Teoh Hui Kee, Fezah Othman Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia Abstract:Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods: Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used: Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results: Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions: Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model. Keywords:Acanthopanax Trifoliatus, Anti-hyperalgesic Carrageenan-evoked Thermal Hyperalgesia, Plantar TestView:PDF (1.11 MB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Attenuating effect of edema of carrageenan-induced KeywordsAcanthopanax TrifoliatusAnti-hyperalgesic Carrageenan-evoked Thermal HyperalgesiaPlantar Test ‹ Anti-arthritic Activity of Root Bark of Oroxylum Indicum (L.) Vent Against Adjuvant-induced Arthritis up Isolation and Identification of Bacterial Endophytes from Pharmaceutical Agarwood-producing Aquilaria Species ›