ArticlesAbstractPharmacognosy Research,2012,4,1,50-56.DOI:10.4103/0974-8490.91040Published:december,2011Type:Original ArticleAuthors:Anil U Tatiya, Sanjay J Surana, Manisha P Sutar, and Nehal H Gamit Author(s) affiliations:Anil U Tatiya, Sanjay J Surana, Manisha P Sutar, Nehal H Gamit Department of Pharmacognosy, Medicinal Plant Research Laboratory, R.C. Patel institute of Pharmaceutical Education and Research, Shirpur - 425 405, Maharashtra, India. Abstract:Background: Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn.(Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. Materials and Methods: Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl 4 ), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB), and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug. Results: Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl 4 and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Conclusion: Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents. Keywords:Andrographis paniculata Nees, Carbon tetrachloride, Hepatoprotective activity, Marker enzymes, Paracetamol, Phyllanthus niruri LinnView:PDF (3.2 MB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Histopathology of liver tissues. Histopathological study of paracetamol-induced hepatotoxicity KeywordsAndrographis paniculata NeesCarbon tetrachlorideHepatoprotective activityMarker enzymesParacetamolPhyllanthus niruri Linn ‹ Moringa Oleifera Lam.: Protease Activity Against Blood Coagulation Cascade up Antihyperglycemic and Antioxidative Effects of the Hydro-methanolic Extract of the Seeds of Caesalpinia Bonduc on Streptozotocin-induced Diabetes in Male Albino Rats ›