ArticlesAbstractPharmacognosy Research,2012,4,1,27-32.DOI:10.4103/0974-8490.91031Published:december,2011Type:Original ArticleAuthors:Poonam Sharma, and Rambir Singh Author(s) affiliations:Poonam Sharma1, Rambir Singh2 1Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India. 2Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India. Abstract:Background: Dichlorvos and lindane pesticide causes toxicity in animals including humans. Ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties. Objective: This study was designed to assess ameliorating effects of ginger juice in dichlorvos and lindane induced neurotoxicity in wistar rats. Materials and Methods: Dichlorvos (8.8 mg/kg bw) and lindane (8.8 mg/kg bw) were orally administered alone as well as in combination to adult male and female wistar rats for 14 days followed by the post-treatment of ginger juice (100 mg/kg bw) for 14 days. Lipid peroxidation (LPO), reduced glutathione (GSH), and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), quinine reductase (QR), and protein level were measured to evaluate the toxicity of these pesticides in brain. Results: Dichlorvos and lindane administration alone and in combination increased LPO and decreased the GSH level, SOD, CAT, GPx, GST, GR, QR activity, and protein. Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the toxicities induced by these pesticides. Post-treatment of ginger juice decreased LPO and increased the level of GSH, SOD, CAT, GPx, GST, GR, QR activity and protein in the brain of rats. Conclusions: The results indicated that dichlorovos and lindane induced tissue damage was ameliorated by ginger juice. Keywords:Dichlorvos, Lindane, Oxidative stress, Reactive oxygen species, Zingiber officinaleView:PDF (693.38 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger KeywordsDichlorvosLindaneOxidative stressReactive oxygen speciesZingiber officinale ‹ Antidepressant-like Effects of Young Green Barley Leaf (Hordeum vulgare L.) in the Mouse Forced Swimming Test up Effect of Butea Monosperma Lam. Leaves and Bark Extracts on Blood Glucose in Streptozotocin-induced Severely Diabetic Rats ›