Modulating Effect of Gmelina arborea Linn. on Immunosuppressed Albino Rats

SH Shukla; AK Saluja; SS Pandya

Modulating Effect of Gmelina arborea Linn. on Immunosuppressed Albino Rats

Articles

Abstract

Pharmacognosy Research,2010,2,6,359-363.

DOI:10.4103/0974-8490.75455

Published:January 2011

Type:Original Article

Authors:

Author(s) affiliations:

SH Shukla¹, AK Saluja², SS Pandya³

¹Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121, India

²A.R.College of Pharmacy, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120, India

³Nutan Education Trust's B. Pharmacy College, At. Rampura, Po. Kakanpur, Tal. Godhra, Dist. Panchmahal, Gujarat - 389 713, India

Abstract:

Aim: In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated. Materials and Methods: Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre. Results: Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count. Conclusion: This drug is found to be a potential immunostimulant.

Keywords:Cellular immunity, Gmelina arborea, Humoral immunity, Immunomodulation