Cytotoxic Acetogenins from Annona glabra Cultivated in Egypt

Ahmed Abdel-Lateff; Bassem S. El-Menshawi; Mohamed Y. Haggag; Mahmoud A. Nawwar

Cytotoxic Acetogenins from Annona glabra Cultivated in Egypt

Articles

Abstract

Pharmacognosy Research,2009,1,3,130-135.

DOI:

Published:January 2010

Type:Original Article

Authors:

Author(s) affiliations:

Ahmed Abdel-lateff¹, Bassem S El-Menshawi², Mohamed Y Haggag³, Mahmoud A Nawwar⁴

¹Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, EGYPT.

²Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, EGYPT.

³Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, EGYPT.

⁴Tanning and Protein Department, National Research Centre Dokki, Giza, EGYPT.

Abstract:

Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.