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ORIGINAL ARTICLE
Year : 2010  |  Volume : 2  |  Issue : 4  |  Page : 215-220

Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract


1 Center for Drug Research, Universiti Sains Malaysia, 11800 Penang, Malaysia
2 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia

Correspondence Address:
Sreenivasan Sasidharan
Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia
Malaysia
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Source of Support: Research University Grant from the University Sains Malaysia., Conflict of Interest: None


DOI: 10.4103/0974-8490.69107

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Background: The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract. Methods: SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice. Results: The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg. Conclusion: This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.


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